Increase size of anchor points / handles
Anchor points and handles are hard to grab.
On denser displays the problem is amplified.
Hard to grab using stylus.

We have the fix available in the latest release. Please update Illustrator using Adobe Creative Cloud application to the latest build for version Illustrator CC 22.1.
Please refer to our knowledge base FAQ – https://illustrator.uservoice.com/knowledgebase/articles/1844590 if you face difficulty in update.
Or get in touch with us at any of the other support channels – https://helpx.adobe.com/support.html
Warm Regards,
Ashutosh Chaturvedi | Sr. Quality Engineering Manager – Illustrator
Adobe. Make It an Experience.
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Dean Jones commented
I have mentioned this MANY times. This is a huge pain **********. On my screen right now, the anchors must be about .015" in size. I can't even tell where they are other than I know where to look.
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Mark Nicoll commented
I'd like this to be customisable in preferences.
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Anonymous commented
My old eyes would appreciate an option to have larger node sizes than the itty-bitty squares and circles we get now.
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Kevin commented
This says 'descibe your idea' despite my clicking bug report!
Bug:
When manipulating bezier curves I often can not grab the control points at the ends of tangent control lines. They simply don't respond - clicking and holding on them with the Anchor Point Tool does not allow me to move them, my pointed just slides off and the point remains unchanged. Repeated trying eventually results in being able to grab and move the point, but it makes Illustrator impossible to use us a quick and flowing way, like I used to.
I have experimented with the settings in Selection & Anchor Display without any improvement.