v.22.0.1 64-bit on win 10
never had these issues before today, but basically some changes are selectively not taking, are reverting back to previous. 2 examples:

1. changed type font from Clyburn to Hummingbird (from Tk), change takes, saved work, then went to move type and reverts to Clyburn. so copied layer with Hummingbird, locked it, hid it, then made change, still switched back. closed/rebooted Illustrator, was back in Clyburn. however, made change and it finally took, however could not change between Hummingbird Regular and Bold.

2. working with ellipses in a logo in CMYK. placed ellipse with gradient stroke. copied layer, copied hex code of 1 color from gradient, applied that color to the copied ellipse, but it put another similar tone. so i verified i had the correct layer selected, went to appearance panel, shift-clicked the stroke color again and this time input the CMYK percentage values, verified the new values took in all 4 fields, butt it stayed the old undesirable color.

these frustrating issues never occurred when using previous versions of Illustrator on both Mac and PC since CS4, CS5, CS5.5, CS6, CC15, and CC17, so i'm pretty sure it's not me but CC18.