"Use Typographer's Quotes" should be added to the Character palette to make it more easily accessible. Sometimes I'm designing a document that uses typographer's quotes, but most of the time I work with documents that reference dimensions in feet and inches, so I need to be able to switch back and forth between typographer's quotes and straight quotes quickly.

In addition to that, "Use Typographer's Quotes" should be moved from File > Document Setup to Illustrator > Settings > Type to match the way Photoshop and InDesign do it.

The Photoshop, Illustrator, and InDesign teams (and probably others, but those are the three apps I use the most) should get together and decide if they want to use to word "Settings" or "Preferences" to describe the same thing. Apple recently changed from using "Preferences" to using "Settings", so that's probably the one to use, at least on macOS.