Publishing PDF files whit PDF/X-4 compatibility for professional printing
PDF files for professional printing are high-quality reproductions of your publication that are passed to a print partner (normally external to your company). You'll typically require a CMYK document, printer marks, bleed, >300dpi images, and PDF/X-1a, PDF/X-3 or PDF/X-4 compatibility (for CMYK output).
Affinity Designer 2 can do it!
https://affinity.help/publisher/English.lproj/index.html?page=pages/Publishing/publishPDFFiles.html&title=Publishing%20PDF%20files
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