Unable to cast COM object of type 'System.__ComObject' to interface type 'Illustrator.Application'.
This operation failed because the QueryInterface call on the COM component for the interface with IID '{95CD20AA-AD72-11D3-B086-0010A4F5C335}' failed due to the following error:

No such interface supported (0x80004002 (E_NOINTERFACE)).

The code
Illustrator.Application appInstance = (Illustrator.Application)Activator.CreateInstance(Type.GetTypeFromProgID("Illustrator.Application"));

Note: Code moved from Windows 10 Intel machine where it works fine.

Thanks for looking into this ... and for a great beta product!