Print Presets should be in RGB or be easier to change to RGB
Most newer printers (Like the HP R530 or Epson Surecolor) handle colors better from files that are in RGB, not CMYK. Would love to have some presets in the "Print" tab be in RGB. Right now it's kind of a pain to change to RGB if you start with a print preset, because you get the warning about the color mode being different from the color space.

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Hmm... All sizes showed under Print Document Profile have to have the same Color Mode, as these are based on the same file.
But we can create our own Document Profiles to allow this. Each one is just a file in folder Ai references when it creates a new document.
On Mac these live here: MacOS <user>/Library/Application Support/Adobe/Adobe Illustrator <version>/<locale>/New Document Profiles/
Create a copy of one, open it, make changes you need (including adding presets you need). Sadly, it won’t show up in the top row if you are using the modern File New UI — that’s one of the main reasons I don’t like it — but it should be there in legacy File New or in More Settings dialog (basically the legacy File New).