Complete user-defined default settings
The work I do for my company has certain defaults that go beyond the layout of my workspace. I only use one font, I always need the same set of color swatches, I use the same tolerance amounts, etc. I export to PDFs the same way every time, I essentially need the same options. (And even with a template, I have to start from scratch for many of these options.)
While I can save certain usual elements in my CC Library, I waste so much time saving and opening and searching. AND even then, I still have to reset the default. - I have to open CC Library, select one of my font styles, one of my paragraph styles (hope that it will work across the board in this document), load my swatches panel, etc.
Even showing print tiling and rulers are two extra steps I do EVERY single time, regardless of if I have opened from a template.
I should be able to set default preferences program-wide to open every document (unless I choose to make those changes on an individual case) with my preferences selected. At very least, my font and color swatches if everything else is shooting for the moon.

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mathias commented
For example:
With the image tracing tool, I don't want to have to open the options every time and select the "ignore the white areas" in a line drawing.
Or what about to set a default font to use when you type a text? Dont know when i realy used Myriad the last time, but i use each day my corporate font…
At the blendoption window, I always have to change the distance from “smooth color” to “fixed steps” first...I would like to be able to define my own basic settings for each command and tool.
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Elaine Wilson commented
Yes. I especially want to change the default settings for a particular effect.
I already have an action set to a key command to delete all the extraneous swatches and styles and symbols that come with a new document, but I shouldn't have to!
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Mike B commented
We would like a clean default document with no bloat.
No Swatches, No Brushes, No Symbols, No Graphic Styles.
When we export logo artwork as EPS, for example, having all these unused items makes the file size larger. -
Cory Burden commented
What is the point to setting preferences in your application when the app will just default back to original settings when reopened?
Make preferences permanent once set until user changes them. -
You can do it.
Create an object, set a stroke (and/or a fill) you like, Alt+drag it over the [Default] style in Graphic Styles panel — this will fix your default settings in this particular document. Same with Character and Paragraph Styles.If you want these changes to be permanent, applied to a new document you create, you should make these changes IN New Document Profile files, located somewhat like here (Windows):
C:\Users\[username]\AppData\Roaming\Adobe\Adobe Illustrator 25 Settings\en_US\x64\New Document Profiles (you can browse this folder, pressing More Settings in New Document dialog’ right pane to call a 'legacy' settings, clicking Profile dropdown and choosing Browse...You might have problems on rewriting these directly in the folder, depending on you user account privileges, so copy them (and backup) first and then overwrite originals, once you set defaults to your needs. Backup these too, because Ai rewrites them when updated.
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Anonymous commented
It should be possible to insert default values manually. Example: Stroke weight or default font by my own choosing. I would like a different font as default.
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Cameron @ Juzvolter Design commented
Forget CC Libraries… they're rubbish.
Save yourself an Illustrator Template file, by opening a new file. Leave your art board blank but set your 'Normal Paragraph Style' to the font etc you want. Set all your swatches, symbols, graphic styles, brushes etc as desired. Even set your art board to the desired size, and maybe add regularly used guides, or layer structure.
Then save it as an Illustrator Template file (.ait) in /Applications/Adobe Illustrator 2020/Cool Extras/en_US/Templates/…
Then when you need to start a new file, select 'New from Template' in the 'File' menu, and select your template file. Illustrator opens a new file .ai based off the template file without disturbing the original. So you can't accidentally save over it. -
Donatas Pabrėža commented
YES!
Please let user choose the default setting by keeping the last used setting when rebooting Ai.
Or by letting users change the default setting in the Preferences panel.
Settings:
1. Magic Wand
2. Align To
3. Pathfinder Precision
...