Thanks for the information provided to the Illustrator team.
We are able to reproduce this issue at our end and the engineering team is currently isolating this issue further to get to the root cause.
With Best Regards,
An error occurred while saving the commentPhilippe Martinez commented
It's 2022. This is still happening. Out of the blue, the spacebar stops being the hand, and zoom shortcuts (spacebar + command, spacebar + command + option) stop working. I'm using the latest Illustrator at the time of writing (2022 26.0.2). Not much else is open on my Mac: Chrome, Acrobat, and the calculator.
When it happens, I use what some other users have recommended: put the computer to sleep then immediately wake it back up using the spacebar. The issue resolves itself. But please: fix the root cause.