Key commands to indicate a selected shape's PROXY location before altering shape.
If I select a shape on the artboard that I want to enlarge while keeping the top left corner in place, I mouse-click the proxy indicator (attached) before the shape modification event.
I wish with all my heart, you could provide key commands for this. It could be something like ALT + X + 1, 2, 3, 4, 5, 6, 7. 8. 9 on the keypad. By selecting number ALT + X + 4 would position the proxy indicator at middle left, to mirror the layout of the number pad.

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This is a great idea. Vote for it here, it has only 7 voices right now:
https://illustrator.uservoice.com/forums/333657-illustrator-feature-requests/suggestions/32403805-make-setting-reference-point-hotkeyable
Also voted here. -
kenwells.com commented
God. That is such a great idea.