Occasionally while I'm in Illustrator, my keyboard shortcuts will randomly stop working for roughly 30 seconds at a time. The issue resolves without me having to restart, but it happens a couple times a day usually. I have custom shortcuts but it also happens for defaults (like cmd + s for saving). I thought it was lag at first, but I'm able to use the same commands from the drop down menus without issue.

I'm running macOS Mojave 10.14.6 with Illustrator 25.4.4, and I have several Esko plug-ins for work.