I suddenly was seeing the "Space Bar Won't enable Hand Tool" problem that's been a plague for years. A few weeks ago, I installed AdGuard for Safari and Mac. I've been happy with it's ad blocking - but this was the culprit for the problem of the Space Bar not invoking the Hand Too, AND for Command+Space not invoking zoom. I've turned off the helpful ad blocker, and I can use my Adobe Apps (Photoshop, Illustrator, InDesign were all affected).
After all these years, PLEASE fix these apps so that our computers can remain usable and safe while still having access to these important tools!