Hi,
Illustrator 25 and Indesign 16 are very very slow with other ICC profiles than AppleRGB and sRGB. For example, if you switch to a profile you created yourself with Eizo colour navigator, Illustrator becomes so slow that you can no longer use it reasonably. Switching to sRGB or AppleRGB is not an option because of the lack of colour binding.
The problem also existed in Lightroom 10.1. and was fixed by the Lightroom developers in 10.2. Maybe the Illustrator teams should get together with the Lightroom teams to fix the problem.
Here is a video showing the problem:
https://youtu.be/S4SKBE7Zn8c

Mac OS 10.15.7
Mac Pro 2014
64gig Ram
2 Graphic adpater Firepro700
4 Displays (Eizo 27", 2560x1440px hardware calibrated; Eizo 31" 4K, hardware calibrated, Eizo24" hardware calibrated, Eizo 24")