I'm working on a Lenovo Yoga ThinkPad with Wacom digitizer.

In normal (notebook) mode, the pen is working properly. However, when flipping the screen and rotating it for hand writing (so that it lies flat in front of me) the Wacom driver breaks. No further input with the pen is possible. Starting the Wacom configuration tool says, the driver is not running. (It was working before properly.) Things are normal again after a reboot - until a flip the screen.

The issue is reproducible and appeared first after the upgrade to Illustrator 2021 (25.4.1) and Windows 10 version 20H2.