On the Home Screen (Preferences > General > Show the Home Screen When No Documents Are Open) the tiles representing the recent documents handle mouse clicks incorrectly.

Currently, to register a MOUSE CLICK event and open the clicked document, the position of the mouse cursor during the MOUSE DOWN event and the subsequent MOUSE UP event must be exactly the same.

Normally, to register a click it's enough that both DOWN and UP events occur within the same active area. It means that the mouse cursor can move while the mouse button is down (between the DOWN and UP events), and the click will still be registered.

For example, this is correct for the same Home Screen, if you try to click on one of the Presets buttons.

This is a minor issue if one uses a mouse. But many graphic designers use graphic tablets. And with a graphic tablet it's very difficult to perform such a click. Meaning that for a significant part of the Illustrator's user base the recent documents section is very inaccessible.