Disabling "Show The Home Screen When No Documents Are Open" corrupts custom workspace
When "Show The Home Screen When No Documents Are Open" in General Preferences is disabled, the next time Illustrator is run, my custom workspace is corrupted, for lack of a better word. The toolbar and all panels are missing, and the Control Panel has become floating.

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David Brown commented
Egor - I appreciate your response. Resetting the corrupted workspace does return it to normal, however that needs to be done each time the document is opened.
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I remember it happening for other reasons, but also when updating, also with the Home Screen disabled, but only when juggling some plugins...
Sometimes using Window > Workspace > Reset helps, sometimes it also requires relaunching Ai, sometimes I need to resave the workspace.