Dear ADOBE. Ive seen several comments from readers offering a solution by switching to CPU and disabling real-time drawing. And some of them even have responses from Adobe asking users to try the same thing. THESE ARE HACKS !! This is unacceptable. You are all like "YAY we've developed Real-time drawing with GPU to make your lives better" but when your customers discover that it screws up a fundamental basic such as guides, the solution appears to be NOT to use the new features !!

You have been 'refining this product since 1989, and you are a multi million dollar giant with huge teams of well paid developers. Just fix the guides !!!!

Guides disappear when moving with the Selection Tool, but not with Direct Selection Tool

Same here. 25.1 still has the same issue. Quite annoying. I entirely switched to operating with numbers within the transform panel instead of doing manual adjustments. I hope Adobe fix it soon.

Same Issue. Guides disappearing while moving them.

Hi, for me the same problem was resolved by switching to CPU (ctrl+E/cmd+E)
AND showing edges (ctrl+H/cmd+H).
This should make the guides visible at any time, while dragging them, too.

Thanks for that - that had me stumped and irritated for a while. They do these updates and have a bunch of boxes pre-checked on the preferences. So - in Preferences under Performance - Just deselect the the Real time Drawing & Editing - problem solved.

I had the same issue and Adobe told me to change some settings while this bug still happens:

Adobe:
Hi there, sorry to hear about this trouble. Could you please try deactivating Real time drawing from Illustrator preferences (Choose Edit > Preferences > Performance > Real-Time Drawing) and see if that helps.

Me:
I attached the bug to this comment.

As somebody stated, it also appears on v25.0.1. I really havent had this problem on v24 so I was baffled when this happened in v25.0.1. I did the Ctrl+E and it worked but the moving of objects and general flow became worse. I unchecked the "Real-Time Drawing and Editing" and it became a bit better. So I think the "Real-Time Drawing and Editing" is the villian here. I use Windows 10 and a laptop of some age but still powerfull for CAD and ofther workloads.
This issue is especially wierd when I am trying to move a completely white object (white fill, no line colour) onto another white object. Thats a challange :)

ctrl+E / cmd+E helped but changing to CPU makes everything all laggy and in this day and age I need this to be streamlined; I just don't have time for this.

SO if you go to Preferences > Performance and look at the bottom of the pop out window and UNCHECK "Real-Time Drawing and Editing" it fixes the whole disappearing guide thing when moving them.

There is no GPU Preview option in Illustrator 25.0.1. The closest option I could find in Preferences is the Performance option (see screenshot). The settings in the screenshot are default. What should they be changed to in order to render my guides when dragging or rotating them?

@Katie it seems that is something with the gpu preview. So in the meanwhile change the gpu preview to cpu: ctrl+E / cmd+E

I am having the same issue when I select two guides and try to move or duplicate them by holding alt and dragging on PC (Windows 10), the guides disappear while they are in motion and reappear when they are motionless. It is impossible to use guides effectively with this buggy issue. Please fix ASAP!!

Has anyone found the solution to the guides issue? The guides are there and visible when you create them, but as soon as you try to move them they disappear???!!? This totally defeats the purpose of guides in general...so ******. This needs to be fixed ASAP!!! I wish I never updated illustrator and Photoshop. This is making my life and I'm sure many others much more difficult.

Same problem and, as a teacher, I find the same bug on several different machines/os/gpu. Please fix it asap!

No, it's not. By default "control/command + E" toggles between GPU/CPU rendering modes. On Retina screens with scale CPU mode is incredibly laggy

Guys, Control/Command + E is the solution to this problem.

It's a huge issue! What sense does it make to not be able to see guides and bounding boxes when moving objects?

Same issue! Guides disappear when moving - defeats the purpose!

Bumping this because it's still an issue for many people

Just update to Illustrator 25 and when I try to click on guides they disappear. They also do it when I move and release them. Disabling Real-time drawing or using CPU view does not fix the issue. Very annoying