@Troyson.Stainy.Self, do you still have this problem with the latest versions of Illustrator?
I try to reproduce it and it works just fine for me, rotated at any angle, at any zoom level.

I hope I chose the right category.
Illustrator will not allow me to move smart guides that have any angle to them when Im zoomed in to 300% or more. This is extremely "I about to break my keyboard" frustrating. This seems to be an on going issue that is "patched" but re-emerges with every other update!

Still a problem as of July, 2019. To think we went to the moon 50 years ago. 🤦🏽‍♂️

this is still a problem in Illustrator CC 23.0.3

I ran into a similar problem. I draw an isometry, so it is important for me that all the guides fit exactly to each other. But when I scale more than 400%, the guides that are tilted (for example, by 60%) do not move. Your support will confirm that I do not have any locks. I updated and
lustrator This is a software error. The horizontal and vertical guides move, and some guides move with an inclination of 13%, for example. Please correct it.

Ritika,

I suggest trying to make a more complex item then a simple shape. I am working on a 30+ page assembly drawing. I cannot select guides when zooming in to components. I have made a new file and loaded in the component and have no luck in moving guides when zoomed in. Believe at 800% mark i cannot select guide. Believe it might be a performance/software issue. If you want I can provide the component in AI file for testing.

thanks,
Ben

OK. Seems like my guides were locked (in the menu, not in the layers).
I wonder why this happened, as I never lock my guides (except in the layers).

Illustrator CC 2018, Windows 10

For me it's the same at any zoom-level. I can't select or move guides at all. I can only create them.

After rotating a guide with any angle thats not a 90 degree one. Illistrator will not allow me to either rotate it again or move the angle guide. This feature does not work when zoomed in at at least 902% or higher. However, when I zoom out to at least 901% or small, it works normally again. This makes work a lot more time consuming constantly zooming in and zooming back out again.

Hi,

Thanks for reporting the bug.
I am unable to reproduce the bug on my end.
It would be helpful if you share your machine details and the exact steps you followed with us.

Regards,
Ritika
Adobe team

Can not select a rotated guide when zoomed-in beyond some specific magnitude

... after updating to 2018